Despite what some people seem to think, Macs are vulnerable to malware. Apple even built limited antivirus capabilities into Snow Leopard.
At the moment, Sophos Antivirus is giving away their Apple version. It could be useful for avoiding the (relatively few) bits of malicious Mac software. Also, for avoiding passing along infected attachments to friends.
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Does Sophos protect against attacks that use vulnerabilities in Flash and Adobe PDF as vectors?
apple.slashdot.org/story/12/02/26/0250203/new-version-of-flashback-trojan-targets-mac-users