Gardasil

Yesterday, I got the my third and final vaccination against the human papillomavirus (HPV). Some strains of this wart-causing virus also cause cancer. The vaccine I bought – Merck’s Gardasil – protects against HPV types 16, 18, 6, and 11. About 70% of cervical cancers are thought to be caused by types 16 and 18, along with most HPV-induced anal, vulvar, vaginal, and penile cancers. About 90% of cases of genital warts are caused by types 6 and 11.

The vaccine isn’t cheap, but I think it would make a huge amount of sense to vaccinate all children with it, or with an improved version that covers even more HPV types. Giving it to all children makes sense because they are relatively unlikely to have already been exposed to HPV, unlike me. Still, even though there is a chance I have already been exposed to one or more types, I think getting the vaccine makes a lot of personal sense. A study of 4,065 males ages 16 to 26 found that over 30 months three men who were vaccinated developed genital warts, compared to 28 cases in a control group given a placebo, and that none of the vaccinated men were found to have pre-cancerous growths linked to HPV, compared with three cases in the placebo group.

The four doctors who were involved in this procedure were all aware that Gardasil can be used to prevent HPV in men as well as a means of protecting future sexual partners (one doctor prescribed the vaccine and three who gave injections over the course of six months). The vaccine is covered by some health plans.

Previously: Getting the HPV vaccine

The End of Nature

In The End of Nature, Middlebury College professor and 350.org founder Bill McKibben makes the case that humanity has put an end to nature by altering the climate, and then goes on to consider the implications. McKibben’s book – first published in 1989 – briefly explains why human activities are increasing the quantity of greenhouse gasses in the atmosphere, and why this will produce change on a planetary scale. His tone is mostly one of lamentation. He expresses sadness about that which is already doomed to destruction, before progressing extensively into the question of what can still be saved, and what means might achieve it. Reading The End of Nature in 2012 is dispiriting. It proves how everything important about climate change was well understood decades ago, including why our political and economic systems have done nothing serious to slow it down. Nonetheless, McKibben’s appeal is a poignant and effective one. By putting humanity’s current activities in context, McKibben conveys the reality that what happens to the Earth now will mostly be a matter of human choices, and that the philosophies we adopt in the decades ahead will affect the prospects of all the life forms that depend upon this planet.

The basic idea of the book is that humanity has no so thoroughly altered the planet that nothing can be considered ‘nature’ in the sense of ‘unpopulated wilderness’ anymore. Climate change is the most important and dramatic change humanity has produced, but our chemical signature is also written in the form of novel isotopes from nuclear tests, changes to the ozone layer, and in the legacy of pollution and pesticides. According to McKibben’s definition, nobody my age has ever seen nature – only nature as modified through human industrial activity.

Along with climate change, McKibben devotes a fair bit of space to talking about genetic engineering. He sees it as a possible way of keeping humanity’s billions alive in a world that is increasingly damaged by our choices. But it is also another step away from ‘nature’. He envisions a world of trees and fish and animals modified to tolerate a changed climate, and modified further to better serve human needs. Reading these passages in 2012, it seems like he over-estimated the importance of genetic engineering, or at least under-estimated how long it would take to arrive. For instance, he imagines custom organisms that draw in nutrients through tubes and produce the parts of chickens many humans enjoy eating. Margaret Atwood’s ‘ChickieNobs’ from the dystopian 2003 novel Oryx and Crake are described in basically identical terms in McKibben’s book, but nothing remotely like them seems to exist in the real world. So far, genetic engineering has been more about experimentation than implementation, and nothing too world-changing seems to have arisen from it. Perhaps that perspective reflects ignorance on my part, especially given the evolving character of the global ‘agribusiness’ and biotechnology industries.

Because I borrowed a copy of the book from a library, rather than buying one, I didn’t take the detailed marginal notes that I usually do when reading a book. I did, however, pick out a few passages that I think are especially evocative and worthy of discussion:

On the habits of humanity

“The problem, in other words, is not simple that burning oil releases carbon dioxide, which happens, by virtue of its molecular structure, to trap the sun’s heat. The problem is that nature, the independent force that has surrounded us since our earliest days, cannot coexist with our numbers and our habits. We may well be able to create a world that can support our numbers and our habits, but it will be an artificial world, a space station.

Or, just possibly, we could change our habits.” (p.144 2006 Random House trade paperback edition)

Timing

“I have tried to explain, though, why [dealing with climate change] cannot be put off any longer. We just happen to be living at the moment when the carbon dioxide has increased to an intolerable level. We just happen to be alive at the moment when if nothing is done before we die the world’s tropical rain forests will become a brown girdle around the planet that will last for millennia. It’s simply our poor luck; it might have been nicer to have been born in 1890 and died in 1960, confident that everything was looking up. We just happen to be living in the decade when genetic engineering is acquiring a momentum that will soon be unstoppable. The comforting idea that we could decide to use such technology to, in the words of Lewis Thomas, cure “most of the unsolved diseases on society’s agenda” and then not use it to straighten trees or grow giant trout seems implausible to me: we’re already doing those things.” (p.165)

On caring for future generations

“We flatter ourselves that we think of the future. Politicians are always talking about our children, our grandchildren, and, as individuals, we do think about them, but in the same way we think about ourselves. We lay aside money for them, or land. But we do not really think of grandchildren in general. “Future generations do not vote; they have no political or financial power; they cannot challenge our decisions,” said a perceptive introduction to the United Nations report on Our Common Future. Future generations depend on us, but not vice versa. “We act as we do because we can get away with it.”” (p.170)

Beyond what one person can deal with

“The inertia of affluence, the push of poverty, the soaring population – these and the other reasons listed earlier make me pessimistic about the changes that we will dramatically alter our ways of thinking and living, that we will turn humble in the face of our troubles.

A purely personal effort is, of course, just a gesture – a good gesture, but a gesture. The greenhouse effect is the first environmental problem we can’t escape by moving to the woods. There are no personal solutions. There is no time to just decide we’ll raise enlightened children and they’ll slowly change the world. (When the problem was that someone might drop the Bomb, it perhaps made sense to bear and raise sane, well-adjusted children in the hope that they’d help prevent the Bomb from being dropped. But the problem now is precisely too many children, well adjusted or otherwise.) We have to be the ones to do it, and simply driving less won’t matter, except as a statement, a way to get other people – many other people – to drive less. Most people have to be persuaded, and persuaded quickly, to change.” (p.174)

So McKibben lays out the challenge that has been occupying some of the most capable and driven people in the world for decades (occupying them, but not yet producing even the beginnings of success) and which seems likely to be the defining activity for humanity as a whole for the decades and centuries ahead.

Since 2007, McKibben has been an important organizer of environmental campaigns and the founder of 350.org, an organization that aims to keep the atmospheric concentration of carbon dioxide below 350 parts per million. Beyond that level, the sensitivity of the Earth to greenhouse gasses is such that we would likely see the disappearance of nations like the Maldives along with large parts of nations like Bangladesh and the Netherlands, accompanied by profound changes to physical and biological systems around the world. Keeping the level of greenhouse gas pollution in the atmosphere below 350ppm is incredibly ambitious and far beyond what any large country on the planet is meaningfully aiming for now. If implemented globally, Canada’s policies would probably put us more in the territory of 1000ppm by 2100 – territory that involves changes so profound that they might threaten the future of the human species, as well as the future of countless other less resilient species in the ecosystems of the world.

The End of Nature is a reminder of the scale of the fight we have on our hands, as well as of the stakes involved. If we are to have any chance of succeeding, we must be committed, passionate, strategic, self-sacrificing and willing to do what has never been done before.

Distrust that Particular Flavor

This book contains about 20 pieces of short writing by William Gibson. They vary in style and content, from his essay on the culture of Singapore (“Disneyland with the Death Penalty”) to long discussions of his history with buying mechanical watches to his thoughts on the future of technology and the societal importance of science fiction.

Not every piece was terribly resonant with me, but I found the book very worthwhile overall. Gibson makes a reasonable case for the importance of technological development in the evolving character of societies, though he may go a bit too far in saying that “all cultural change is essentially technologically driven” (p.123 hardcover).

Googling the Cyborg” was probably the most interesting essay – discussing the way in which human biology and technology have already started to compliment one another to a remarkable degree.

Trying the same thing and expecting a different result

I’m sure everyone has heard this quote and its variations: “The definition of insanity is doing the same thing and expecting a different result”.

While it may have a kind of folksy charm, I think the position being argued here is plainly false. While there will never be a simple an unambiguous definition for a concept as subjective as ‘insanity’, I think the definition above can be effectively refuted.

First, we need to be careful about what we mean by ‘the same thing’. A man trying to open a pickle jar is likely to do ‘the same thing’ several times – trying to twist off the lid in what he believes to be the right direction. Frequently, the repeated application of effort will do the job. It can be argued that this doesn’t contradict the original claim. ‘Twisting the lid of a pickle jar that I have already twisted five times’ is not ‘the same thing’ as ‘twisting the lid of a pickle jar that I have already twisted four times’. Fair enough, but this interpretation supports the view that repeating the same behaviour can be an intelligent and successful strategy, rather than the mark of mental imbalance.

Second, there is a reasonably admirable practicality involved when a person tries something several times and notes whether the result changes. I might try throwing five darts at a dart board and get a different result with each one. Less trivially, I might apply to ten graduate schools and get a range of answers. In these circumstances, my expectations are more complex than ‘same result’ or ‘different result’. I may well get into nuanced claims like: “I thought it was pretty likely I would hit the dart board, but I had no idea where” or “I am likely to get into some schools, but probably not all of the most prestigious ones’.

The world often involves complicated interactions between phenomena that incorportate chaotic elements. In a world like that, trying the same thing over and over can be an essential way of sorting out what the governing dynamics of a relationship really are. The fact that trial and observation are at the heart of the scientific method are probably why this flippant witticism annoys me so much.

As is often the case, XKCD has already made this point in a more effective and eloquent way than I can.

Gambling with high stakes

As with other high-risk activities, I think gambling on climate change is irresponsible and reckless, even if the people making that bet turn out to be right.

If a person runs across a minefield in order to experience the thrill of danger, few people are likely to congratulate them for their bold choice in the face of uncertainty. Even if you get away with it, it is foolish to run careless risks, especially when the consequences of getting it wrong are severe. This is why Russian Roulette is commonly regarded as an absurdly irresponsible pastime.

Say there is some powerful negative feedback that climate scientists haven’t yet identified. And say it manages to reduce the severity of climate change substantially. Imagine it is 2100 and we are looking back at 2012. I think the people considering the problem from that vantage would be quite willing to recognize how scary climate change looked in 2012. I also think they would be willing to chastise us for our inactivity on the problem, even in a scenario where it worked out that our most extreme fears for what climate change might mean weren’t recognized. Rather than being concerned about climate change ‘alarmists’ who called for action, I suspect impartial citizens in 2100 would be critical of the people who wanted us to plow heedlessly on with fossil fuel development, despite the serious outstanding questions on what effect that would have on the future of human civilization.

From any rational perspective, it makes sense for the world as a whole to take serious action to reduce the seriousness of climate change and the probability of extremely bad outcomes. The problem is that this course of action is not in the short-term interests of many individuals, including powerful people whose wealth and influence is rooted in the status quo.

The real question, when it comes to climate change, is how to make individuals, companies, and countries behave more like they would if they were taking the rights and welfare of everybody seriously. Something like the Categorical Imperative (or even the Harm Principle) provides the moral backing for this view. The question is how to discourage selfish and destructive behaviour while encouraging the cooperation and sacrifice that are required to protect the planet and discharge our duties with respect to future generations.

Software defined radio

Software defined radio (SDR) is one of the things I am most curious about. There is just so much data being exchanged via radio these days. It’s strange to think about the constant complex pattern of broadcasting happening all around us.

This video gives a bit of a taste of what is happening in one part of the world and across a fairly narrow range of frequencies:

It’s pretty cool that he is able to identify and analyze Chinese over-the-horizon RADAR. It shows some of the possibilities SDR opens up for hobbyists.

Much of the hardware required to seriously experiment with SDR is expensive. Interestingly, though, someone has figured out how to do the job for the 64-1700MHz frequency band using an $11 digital TV tuner chip.

You could do some very cool stuff with this: set up your own infrastructure independent computer networks, explore what sort of communication is happening around you, conduct intrusion detection (looking for interception devices broadcasting), and experiment with the security of your hardware, such as the Bluetooth chips in your phone and laptop.

Open thread: Antibiotic resistance

I frequently see interesting stories about antibiotic resistance, and it seems to be quite an important issue. Back in 2008, I wrote about a Canadian initiative to try to deal with the dangerous bugs.

More recently, tuberculosis has progressed from extensively drug-resistant TB (XDR-TB) to “totally drug-resistant TB” (TDR-TB).

We are going to need some new antibiotics.

2012 vernal equinox

The coming of spring is an astronomical and biological phenomenon.

The moment of the vernal equinox – the start of spring in the northern hemisphere – is the moment where the length of days is changing fastest. Biologically, spring is characterized by the re-emergence of life. In particular, it is characterized by the resumption of productive photosynthesis as leaf-bearing plants deploy their solar collectors to take advantage of longer days. This process, along with organic decay during the darker months, gives the Keeling Curve its characteristic wiggles.

In a way, each spring is a dawn for renewable energy. Aside from a few chemical-eating bugs in the ocean, pretty much all life on Earth is ultimately powered by sunlight as processed by photosynthetic organisms. Spring shows how the vast energy output of the sun can be used in the service of life.